| Away Team | Streak | + OR - | Home Team | Streak | + or - |
| Atlanta Falcons - W1L2 - 110/113 = -3 (-1.3%) | W 1 | - 0 | at | Arizona Cardinals +2.5 | L 2 | - 2 |
| Buffalo Bills - W1L3 - 64/58 = 6 (4.9%) | W 1 | - 2 | at | Cleveland Browns +10.0 | L 3 | - 2 | *** |
| Cincinnati Bengals - L1L1 - 224/224 = 0 (0.0%) | L 1 | - 2 | at | Miami Dophins +4.0 | L 1 | 0 |
| Green Bay Packers - L1W1 - 228/218 = 10 (2.2%) | L 1 | - 2 | at | Chicago Bears -1.5 | W 1 | + 2 | *** |
| Jacksonville Jaguars - W5W1 - 12/19 = -7 (-22.6%) | W 5 | + 4 | at | Denver Broncos -3.0 | W 1 | - 2 | *** |
| Kansas City Chiefs - L6L1 - 7/3 = 4 (40.0%) | L 6 | - 4 | at | Tennessee TITANS +3.5 | L 1 | - 2 | *** |
| Los Angeles Chargers - W3L2 - 25/26 = -1 (-2.0%) | W 3 | + 2 | at | Dallas Cowboys -2.5 | L 2 | 0 | *** |
| Los Angeles Rams - W2L1 - 107/121 = -14 (-6.1%) | W 2 | + 6 | at | Seattle Seahawks -1.5 | L 1 | + 6 |
| Minnesota Vikings - W2L2 - 52/58 = -6 (-5.5%) | W 2 | - 4 | at | New York Giants +3.0 | L 2 | 0 | *** |
| New England Patriots - L1W1 - 228/218 = 10 (2.2%) | L 1 | + 4 | at | Baltimore Ravens -3.0 | W 1 | - 2 | *** |
| New York Jets - L2W3 - 26/25 = 1 (2.0%) | L 2 | - 0 | at | New Orleans Saints -4.0 | W 3 | - 2 | *** |
| Las Vegas Raiders - L1W4 - 31/31 = 0 (0.0%) | L 1 | - 2 | at | Houston Texans -14.0 | W 4 | + 2 | *** |
| Philadelphia Eagles - W1W1 - 220/220 = 0 (0.0%) | W 1 | + 2 | at | Washington Football Team +6.5 | W 1 | - 4 | *** |
| Pittsburgh Steelers - W2L1 - 107/121 = -14 (-6.1%) | W 2 | - 0 | at | Detroit Lions -7.0 | L 1 | 0 |
| San Francisco 49ers - W4W1 - 28/24 = 4 (7.7%) | W 4 | + 4 | at | Indianapolis Colts +6.0 | W 1 | + 2 |
| Tampa Bay Buccaneers - L6L1 - 7/3 = 4 (40.0%) | L 6 | - 4 | at | Carolina Panthers +3.0 | L 1 | + 2 | *** |